Cyclizine dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cyclizine DiHClide 是一种组胺 H1 拮抗剂。它通过口服或肠胃外给药，用于控制术后和药物引起的呕吐以及晕动病。

Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.

Cyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.

Cyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner. Animal Model:Naive male CDI mice (Charles River) weighing 25-30 g Dosage:1, 10 mg/kg Administration:s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.Result:Enhanced locomotor activity in a dose-dependent manner.

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Others

Other Targets

H1 receptor

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5897-18-7

339.3

C18H24Cl2N2

>98% (HPLC)

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CN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years